Methylated B12 (60 CT)

• Includes High-Concentration, Fast-Absorbing Bioactive Methylcobalamin and Methylfolate (100% as 5-MTHF)
• Boosts Energy Levels and Supports Red Blood Cell Production 
• Promotes Cardiovascular Health and Homocysteine Balance
• Rejuvenates Nerve Cell Function and Boosts Cognitive Health
• Supports a Positive Mood and Healthy Sleep Cycle Regulation

Vitamin B₁₂ works along with folate in many body processes, including increasing metabolic energy and red blood cell production, supporting mood regulation and cognitive function, up-regulating methylation, increasing DNA synthesis and repair, and supporting the formation of the protective myelin sheath, the insulating exterior that speeds up nerve cell transmission.

Most B₁₂ supplements contain cyanocobalamin. In order for B12 to be utilized in the body, the liver must first remove the cyanide molecule and attach a methyl group to form methylcobalamin, the biologically active, tissue-ready form. Research has shown that methylcobalamin is more efficiently used and retained in the body than the cyanocobalamin form.

This formulation of Methyl B₁₂ includes a concentrated and bioavailable source of two key B vitamins: B₁₂ and folate. Each tablet provides 5,000 mcg of methylcobalamin and 1,700 mcg of folate as Quatrefolic® -100% 5-MTHF. This synergistic blend of methyl-donating B vitamins quickly boosts tissue and brain levels to support numerous systems in the body.

Energy Support

Vitamin B₁₂ plays a large role as a cofactor in enzymes involved in the metabolism of proteins, fats and carbohydrates, and is required to produce succinyl CoA, an intermediary in the Kreb's cycle that generates cellular energy in the form of adenosine triphosphate (ATP). Due to its role in the production of ATP, vitamin B₁₂deficiency is often characterized by fatigue and weakness. Supplementation with methylcobalamin and 5-MTHF has been shown to promote increased energy levels.

Peripheral Circulation and Nerve Cell Health

In a double-blind study, oral administration of methylcobalamin (500 mcg three times daily for four months) showed a significant improvement in neuromuscular health. The subjects in the control group reported improvement in muscle aches, fatigue, sensitivity to pain, circulation, muscle cramps and reflexes.

Cardiovascular Health and Homocysteine Balance

Homocysteine is a molecule which is synthesized in the body from the amino acid methionine. Maintaining healthy homocysteine balance is crucial for supporting arterial and cardiovascular health. Both 5-MTHF and methylcobalamin are required to maintain optimal homocysteine balance. 5-MTHF acts as a methyl donor, providing a methyl group to vitamin B₁₂. The methylated form of B₁₂ (methylcobalamin) then transfers the methyl group to homocysteine, resulting in consistent recycling of homocysteine to methionine.

Mental and Cognitive Health

B₁₂ has been shown to be beneficial for maintaining a positive mental outlook because it acts as a methyl donor and increases the synthesis of s-adenosylmethionine (SAM-e), a nutrient that has powerful mood and sleep-cycle regulating properties. Due to B₁₂’s ability to increase the production of neurotransmitters and nerve cell transmission, B₁₂ has been shown to improve cognitive function. 5-MTHF plays a significant role in mood regulation as it is required as a methyl group donor for the production of neurotransmitters such as serotonin.

Sleep Cycle Regulation

Methylcobalamin and 5-MTHF are both required nutrients for the biosynthesis of melatonin, the hormone that helps induce sleep. Within the central nervous system, the neurotransmitter serotonin is converted into melatonin in a pathway that requires the donation of a methyl group.